Multiple analytical methods for determination of formoterol and glycopyrronium simultaneously in their novel combined metered dose inhaler

Table 6 Assay results for the determination of the FF and GLY in their synthetic mixture by the proposed IPC and reference methods

	Proposed IPC method (synthetic mixture)				Reference method [39]
	Conc. taken (μg/mL)		% Found^a		Conc. taken (μg/mL)		% Found^a
	FF	GLY	FF	GLY	FF	GLY	FF	GLY
Data	3.6	6.75	99.42	100.12	9.6	13.5	99.38	99.58
	3.0	5.625	99.34	100.82	7.2	11.25	98.34	98.32
	2.4	4.5	100.35	100.4	4.8	9.0	99.25	99.25
	1.8	3.375	100.97	100.35	3.6	6.75	100.38	99.87
	1.2	2.25	99.57	99.49	2.4	4.5	99.07	100.77
	0.6	1.125	99.34	99.18	1.2	2.25	98.34	100.82
\({\bar{\text{X}}}\)			99.83	100.06			99.13	99.77
± SD			0.68	0.61			0.76	0.95
t-value			1.7 (10.0)	0.63 (10.0)
F-value			1.27 (5.5)	2.41 (5.5)

Nominal content for GLY in Bevespi^® aerosphere by the proposed method = 9.0 μg/buff
Each result is the average of three separate determinations
^aNominal content for FF in Bevespi^® aerosphere by the proposed method = 4.8 μg/buff

ISSN: 2661-801X