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Table 5 Statistical comparison of the results obtained by the proposed methods and reference methods for the determination of PAR, PSE and BRM

From: Analytical methods for the determination of paracetamol, pseudoephedrine and brompheniramine in Comtrex tablets

 

PAR

Ref. [29]

PSE

Ref. [29]

BRM

Ref. [26]

TLC

HPLC

UPLC

TLC

HPLC

UPLC

TLC

HPLC

UPLC

Mean

99.46

100.67

99.55

99.40

99.74

99.02

98.99

100.11

100.02

100.32

98.28

99.12

SD

1.569

1.430

1.270

0.778

1.090

1.171

1.11

0.427

0.735

1.521

0.910

0.699

N

6

6

6

4

6

6

6

4

6

6

6

4

Variance

2.462

2.045

1.613

0.605

1.188

1.371

1.232

0.182

0.540

2.310

0.828

0.489

Student’s t

0.080 (2.310)

1.611 (2.310)

0.374 (2.310)

 

0.640 (2.310)

1.762 (2.310)

1.870 (2.310)

 

1.920 (2.310)

1.464 (2.310)

1.586 (2.310)

 

F

4.07 (9.01)

3.38 (9.01)

2.67 (9.01)

6.53 (9.01)

7.52 (9.01)

6.77 (9.01)

1.10 (9.01)

4.72 (9.01)

1.69 (9.01)

  1. Figures between parentheses represent the corresponding tabulated values of t and F at P = 0.05
  2. Reported method for determination of PAR and PSE is an HPLC method using C18 column, a mobile phase composed of 25 mM phosphate buffer (pH = 5):methanol:acetonitrile (30:60:10, v/v/v) at flow rate 1 mL/min and detection at 240 nm
  3. Reported method for determination of BRM is a TLC using methanol:ammonia (100:1.5 v/v) as mobile phase