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Table 1 LC–MS/MS parameters selected for the quantification of metformin and canagliflozin using propranolol and tadalafil as internal standards

From: Novel LC–MS/MS method for analysis of metformin and canagliflozin in human plasma: application to a pharmacokinetic study

Analyte Q1 (m/z) Q3 (m/z) DP (v) EP (v) CE (v) CEP (v)
Metformin 130.2 60.1 26 10 19 12
Canagliflozin 462.3 191.2 61 10 15 18
Propranolol HCl 260.2 183.0 120 10 28 12
Tadalafil 390.2 268.2 73 10 50 17.4
  1. Q1: precursor ion; Q3: product ion; DP: declustering potential; EP: entrance potential; CE: collision energy; CEP: cell exit potential