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Table 1 LC–MS/MS parameters selected for the quantification of metformin and canagliflozin using propranolol and tadalafil as internal standards

From: Novel LC–MS/MS method for analysis of metformin and canagliflozin in human plasma: application to a pharmacokinetic study

Analyte

Q1 (m/z)

Q3 (m/z)

DP (v)

EP (v)

CE (v)

CEP (v)

Metformin

130.2

60.1

26

10

19

12

Canagliflozin

462.3

191.2

61

10

15

18

Propranolol HCl

260.2

183.0

120

10

28

12

Tadalafil

390.2

268.2

73

10

50

17.4

  1. Q1: precursor ion; Q3: product ion; DP: declustering potential; EP: entrance potential; CE: collision energy; CEP: cell exit potential