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Table 3 Recovery data and matrix effect for the determination of metformin and canagliflozin by the proposed method in human plasma

From: Novel LC–MS/MS method for analysis of metformin and canagliflozin in human plasma: application to a pharmacokinetic study

 

QC level

Metformin

Canagliflozin

Recovery%

RSD%

Recovery%

RSD%

Recovery data

LQC

98.55

3.379

90.12

3.776

MQC

97.69

6.766

94.04

7.149

HQC

98.40

3.493

98.79

6.077

Matrix effect

LQC

98.43

6.075

95.95

13.136

HQC

96.26

4.083

104.98

5.887

  1. Mean percentage recovery and RSD were calculated using six lots of plasma samples