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Table 3 Recovery data and matrix effect for the determination of metformin and canagliflozin by the proposed method in human plasma

From: Novel LC–MS/MS method for analysis of metformin and canagliflozin in human plasma: application to a pharmacokinetic study

  QC level Metformin Canagliflozin
Recovery% RSD% Recovery% RSD%
Recovery data LQC 98.55 3.379 90.12 3.776
MQC 97.69 6.766 94.04 7.149
HQC 98.40 3.493 98.79 6.077
Matrix effect LQC 98.43 6.075 95.95 13.136
HQC 96.26 4.083 104.98 5.887
  1. Mean percentage recovery and RSD were calculated using six lots of plasma samples