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Table 5 Pharmacokinetic parameters for metformin and canagliflozin following oral administration of one Vokanamet® nominally containing 850 mg of metformin and 50 mg of canagliflozin

From: Novel LC–MS/MS method for analysis of metformin and canagliflozin in human plasma: application to a pharmacokinetic study

PK parameter Metformin Canagliflozin
tmax (h) 3.5 ± 0.71 4 ± 0.0
Cmax (ng/mL) 1197.50 ± 470.23 383.13 ± 62.41
AUC0−t (ng h/mL) 11849.18 ± 5871.57 3409.06 ± 208.50
AUC0−∞ (ng h/mL) 12575.62 ± 6220.67 3962.65 ± 223.77
t1/2 (h) 6.03 ± 0.62 8.19 ± 0.06
Kel (h−1) 0.12 ± 0.01 0.08 ± 0.01