From: Synthesis of some novel 2-(3-cyano -6-(thiophen- 2-yl)-4,4′- bipyridin-2- yloxy)acetohydrazide derivatives: assessment of their cytotoxic activity
Compounds
MCF-7 IC50 (µg)
Dox.
1.6 ± 0.02
1
4 ± 0.18
2
8.2 ± 0.7
3
1.3 ± 0.04
5
28.7 ± 1.4
6
4.7 ± 0.3
7a
3.5 ± 0.2
7b
4.4 ± 0.2
7c
0.6 ± 0.01
7d
2.7 ± 0.04
8
3 ± 0.2