Codes | R1 | R2 | R' | ALR1 | ALR2 |
---|---|---|---|---|---|
IC50 ± SEM (µM)/% inhibition | |||||
3a | OH | OCH3 | C6H5NH2 | 5.38 ± 0.07 | 0.25 ± 0.04 |
3b | OH | OCH3 | C4H9NO | 6.07 ± 0.05 | 19.2 ± 0.08 |
3c | OH | OCH3 | C7H7NO3 | 2.38 ± 0.02 | 6.38 ± 0.01 |
3d | OH | OCH3 | C7H7NO2 | 3.76 ± 0.09 | 7.36 ± 0.02 |
3e | OCH3 | H | C6H5NH2 | 2.87 ± 0.01 | 12.71 ± 0.09 |
3f | OCH3 | H | C4H9NO | 2.18 ± 0.03 | 0.12 ± 0.01 |
3g | OH | OCH3 | C4H9N | 2.22 ± 0.04 | 2.42 ± 0.03 |
Valproic acid |  |  |  | 57.4 ± 0.89 | – |
Sulindac |  |  |  | – | 0.29 ± 0.08 |