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Fig. 11 | BMC Chemistry

Fig. 11

From: Design, computational studies, synthesis and in vitro antimicrobial evaluation of benzimidazole based thio-oxadiazole and thio-thiadiazole analogues

Fig. 11

Scheme of preparation of compounds 5a-d, 6a-c, 8a-d and 9a-c (a) dry K2CO3, 18-crown-6, methyl 3-bromopropionate, anhydrous DMF, overnight, 60 °C (b) NH2NH2. H2O, ethanol, overnight, r.t (c) KOH, CS2, absolute ethanol, overnight, 80 °C, 1 N HCl/H2O, (d) KOH, CS2, absolute ethanol, overnight, 80 °C, conc.H2SO4/H2O (e) K2CO3, anhydrous DMF, appropriate alkyl halide, overnight, r.t

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