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Table 1 The IC50 of the synthesized compound against three different cancer cell lines

From: Design, synthesis, molecular docking studies and biological evaluation of thiazole carboxamide derivatives as COX inhibitors

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IC50

Compound Code

R

Huh7

MCF-7

HCT116

2a

H

> 40

> 40

> 40

2b

3,4-OCH3

> 40

> 40

> 40

2c

3,5-OCH3

NI

NI

NI

2d

2,5-OCH3

NI

NI

NI

2e

2,4-OCH3

NI

> 40

35.70 ± 0.79

2f

3,4,5-OCH3

17.47 ± 0.85

NI

14.57 ± 0.93

2g

2,5-OCH3, 4-CL

NI

NI

NI

2h

4-t-butyl

> 40

NI

> 40

2i

4-thiophene

NI

NI

NI

  1. NI: no inhibition, > 40: inhibition was observed at concentrations higher than 40 µM
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BMC Chemistry

ISSN: 2661-801X

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