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Table 4 Antimicrobial screening results of pefloxacin and its complexes evaluated by the mean inhibition zone in mm

From: A perception into binary and ternary copper (II) complexes: synthesis, characterization, DFT modeling, antimicrobial activity, protein binding screen, and amino acid interaction

Compound

Gram negative bacteria

Gram positive bacteria

Fungi

Escherichia coli

Pseudomonas aeruginosa

Streptococcus pneumonia

Bacillus subtilis

Aspergillus fumigatus

Candida albicans

Pefloxacin mesylate dihydrate

22.4 ± 0.63

nda

21.2 ± 0.63

23.2 ± 0.63

nda

nda

[Cu(Pf)2(H2O)2].3H2O

22.1 ± 0.72

nda

24.3 ± 1.2

25.4 ± 0.58

18.3 ± 0.63

nda

[Cu(HPf)(bipy)(NO3)]NO3.2H2O

21.6 ± 0.63

nda

19.6 ± 1.2

20.8 ± 0.63

nda

nda

[Cu(HPf)(phen)(NO3)]NO3.2H2O

20.3 ± 0.63

nda

18.3 ± 0.58

18.9 ± 0.25

nda

nda

Amphotericin B

    

23.7 ± 0.1

25.4 ± 0.1

Ampicillin

  

23.8 ± 0.2

32.4 ± 0.3

  

Gentamicin

19.9 ± 0.3

17.3 ± 0.1

    
  1. nda = no detected activity