Indole-carbohydrazide linked phenoxy-1,2,3-triazole-N-phenylacetamide derivatives as potent α-glucosidase inhibitors: design, synthesis, in vitro α-glucosidase inhibition, and computational studies

Table 1 Structures and anti-α-glucosidase activities (IC₅₀ values, µM) of indole-carbohydrazide-phenoxy-1,2,3-triazole-N-phenylacetamide derivatives 11a–o

Compound	R¹	R²	IC₅₀ (µM)
11a	H	H	15.21 ± 0.18
11b	H	2-CH₃	8.88 ± 0.07
11c	H	4-CH₃	19.12 ± 0.08
11d	H	4-OCH₃	6.31 ± 0.03
11e	H	2-Cl	26.97 ± 0.25
11f	H	4-Cl	9.53 ± 0.12
11g	H	4-Br	49.89 ± 0.09
11h	H	4-NO₂-3-CH₃	35.11 ± 0.07
11i	OCH₃	H	11.25 ± 0.15
11j	OCH₃	4-OCH₃	24.19 ± 0.1
11k	OCH₃	4-Cl	31.56 ± 0.12
11l	OCH₃	2,3-Dichloro	18.2 ± 0.81
11m	OCH₃	3,5-Dichloro	14.2 ± 0.21
11n	OCH₃	4-Br	8.3 ± 0.16
11o	OCH₃	2-Cl-3-NO₂	12.67 ± 0.05
Acarbose	–	-	750.0 ± 10.0

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