Fig. 9From: Indole-based FLT3 inhibitors and related scaffolds as potential therapeutic agents for acute myeloid leukemiaSimple 2D diagram of the predicted binding modes of compound 18 the ATP binding domain of PDGFRα (PDB: 5GRN); illustrating the two main hydrogen bonding interactions of compound 18 with Cys694 in hinge domain, and various π-π stacking interactions with Leu599, Val607, Leu825, and Phe837 amino acids residues adjacent to the adenine binding siteBack to article page