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Table 4 System suitability parameters of the suggested MUPLC method

From: Earth-friendly micellar UPLC technique for determination of four hypoglycemic drugs in different pharmaceutical dosage forms and spiked human plasma

Parameter

Obtained value

Recommended value *

PIO

ALO

GLM

VLD

Resolution (R s )

     

PIO

ALO

GLM

…….

8.88

13.94

5.12

17.82

9.03

3.91

> 2

Selectivity (α)

     

PIO

ALO

GLM

…….

2.25

2.99

1.33

3.56

1.58

1.19

> 1

Tailing factor (T)

1.15

1.05

1.32

1.02

< 2

Theoretical plate number (N)

2152.32

4019.47

6788.88

9376.37

> 2000

Capacity factor (K`)

0.82

3.11

4.46

5.50

1–10 acceptable

  1. *Values defined by FDA Center of Drug Evaluation and Research’s reviewer guidance on validation of chromatographic methods (November 1994)
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BMC Chemistry

ISSN: 2661-801X

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