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Table 6 Statistical analysis of the results obtained by applying the proposed MUPLC method and the reported method for the determination of ALO, VLD, PIO, and GLM in different pharmaceutical dosage forms

From: Earth-friendly micellar UPLC technique for determination of four hypoglycemic drugs in different pharmaceutical dosage forms and spiked human plasma

Parameter

Proposed method

PIO/ALO

PIO/GLM

ALO

VLD

PIO

ALO

PIO

GLM

N

5

5

5

5

5

5

Mean *

101.23

100.57

101.43

99.62

100.88

101.33

SD

1.738

1.085

1.212

1.729

1.761

0.504

Variance

3.021

1.177

1.470

2.989

3.101

0.254

Student t-test (6.39) **

0.15

0.34

1.29

0.31

0.41

1.23

The Variance ratio F-test (2.31) **

1.22

1.91

1.56

1.10

3.06

1.48

Parameter

Reported method

PIO/ALO [18]

PIO/GLM [27]

ALO [43]

VLD [44]

PIO

ALO

PIO

GLM

N

5

5

5

5

5

5

Mean *

101.38

100.77

100.31

99.95

100.50

100.89

SD

1.577

0.784

1.514

1.646

1.007

0.614

Variance

2.486

0.615

2.291

2.709

1.015

0.377

  1. *Average of five experiments
  2. **Figures between parentheses represent the corresponding tabulated values of t and F at P = 0.05
  3. HPLC method [18] (C18 column, using phosphate buffer (pH 3) and methanol (45:55 v/v) at a flow rate of 0.3 mL/min and UV detection at 280 nm)
  4. HPLC method [27] (C18 column, using acetonitrile and ammonium acetate (pH 4.5; 20 mM) 60:40 (v/v) at a flow rate of 1.0 mL/min and UV detection at 230 nm)
  5. HPLC method [43] (C18 column, methanol: double distilled water (80:20, v/v) at a flow rate of 1 mL/min and UV detection at 222 nm)
  6. HPLC method [44] (C18 column, using acetonitrile:0.02 M potassium di-hydrogen Phosphate (pH 4.5) (25:75 v/v) at a flow rate of 1.0 mL/min and UV detection at 215 nm)
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BMC Chemistry

ISSN: 2661-801X

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