Mathematical processing of absorption as green smart spectrophotometric methods for concurrent assay of hepatitis C antiviral drugs, Sofosbuvir and Simeprevir: application to combined pharmaceutical dosage forms and evaluation of the method greenness

Table 1 Analytical performance data for the calibration by using different methods for determination of SOF with SMV

Parameter	SMV (335 nm)	SOF
Parameter	SMV (335 nm)	Method (I)	Method (II)	Method (III)
Linear range (µg mL⁻¹)	3.0–50.0	2.0–50.0	2.0–50.0	4.0–50.0
Slope	0.0150	0.0114	0.0179	0.0179
Intercept	0.0277	0.0893	0.0605	0.0173
Standard deviation of intercept	0.0021	0.0021	0.0028	0.0029
Correlation Coefficient (r)	0.9999	0.9998	0.9998	0.9999
LOD (µg mL⁻¹)	0.47	0.60	0.53	0.54
LOQ (µg mL⁻¹)	1.44	1.84	1.60	1.64

ISSN: 2661-801X