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Table 2 Determination of SOF and SMV concentration in laboratory mixtures by the different proposed methods

From: Mathematical processing of absorption as green smart spectrophotometric methods for concurrent assay of hepatitis C antiviral drugs, Sofosbuvir and Simeprevir: application to combined pharmaceutical dosage forms and evaluation of the method greenness

Mix

Ratio

% Recoverya

SMV (335 nm)

SOF

Method I

Method II

Method III

1

1:1

100.56

101.66

100.10

102.21

2

1: 2

99.21

102.67

101.33

99.67

3

2:1

101.56

99.98

99.78

100.18

4

1:3

100.83

99.82

100.89

101.34

5

3:1

99.69

98.92

99.69

102.06

6

2:3

101.55

100.72

101.46

101.35

7

3:2

101.94

99.69

100.55

100.96

Mean

100.76

100.49

100.54

101.11

SD

1.02

1.29

0.71

0.92

% RSD

1.01

1.28

0.71

0.93

  1. athe value is the mean of three determinations
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BMC Chemistry

ISSN: 2661-801X

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