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Table 4 Determination of dosage form in laboratory synthetic mixture of studied drugs and comparison with reported TLC-Spectro-Densitometric method

From: Mathematical processing of absorption as green smart spectrophotometric methods for concurrent assay of hepatitis C antiviral drugs, Sofosbuvir and Simeprevir: application to combined pharmaceutical dosage forms and evaluation of the method greenness

Method

% Recoverya ± SD

SOF

SMV

iso-absorptive point

102.12 ± 1.21

(t = 1.91, F = 1.88)b

 

Ratio subtraction

99.83 ± 1.78

(t = 1.56, F = 3.67)

100.53 ± 1.78c

(t = 0.98, F = 2.55)

Dual wavelength

100.78 ± 1.88

(t = 1.46, F = 4. 77)

 

Reported methods18

100.01 ± 1.52

99.47 ± 1.39

  1. athe value is the average of five measurements for both the proposed and reported methods
  2. bthe values in parentheses are t- value and F- value. Tabulated values at 95% confidence limit are t = 2.306 and F = 6.338
  3. cSMV was determined by measuring the absorbance at λ 335 nm in all methods
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BMC Chemistry

ISSN: 2661-801X

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