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Table 5 Analysis of pure studied drugs in presence of some common tablet and capsule excipients (1.0 mg mL−1) using the proposed methods

From: Mathematical processing of absorption as green smart spectrophotometric methods for concurrent assay of hepatitis C antiviral drugs, Sofosbuvir and Simeprevir: application to combined pharmaceutical dosage forms and evaluation of the method greenness

Excipients

% Recovery ± SD*

SMV (335 nm)

SOF

Method I

Method II

Method III

Titanium dioxide

100.63 ± 0.89

99.63 ± 0.99

102.09 ± 0.54

98.89 ± 1.25

Lactose monohydrate

101.16 ± 1.79

100.16 ± 1.55

100.57 ± 1.93

100.50 ± .1.71

Magnesium stearate

99.88 ± 1.65

98.88 ± 2.00

101.98 ± 1.69

101.83 ± 0.63

Talc

99.87 ± 0.98

101.00 ± 1.78

99.09 ± 1.02

100.40 ± 1.33

  1. *Mean value of three determinations, (SD) standard deviation
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BMC Chemistry

ISSN: 2661-801X

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