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Table 6 Determination of pure powder in laboratory synthetic mixture of studied drugs and comparison with reported method

From: Mathematical processing of absorption as green smart spectrophotometric methods for concurrent assay of hepatitis C antiviral drugs, Sofosbuvir and Simeprevir: application to combined pharmaceutical dosage forms and evaluation of the method greenness

Method

% Recoverya ± SD

SOF

SMV c

iso-absorptive point

99.63 ± 1.00

(t = 0.97, F = 1.58)b

 

Ratio subtraction

100.16 ± 1.55

(t = 1.33, F = 2.55)

101.22 ± 1.55

(t = 1.98, F = 1.78)

Dual wavelength

101.98 ± 1.69

(t = 1.88, F = 3. 54)

 

Reported methods18

100.01 ± 1.52

99.47 ± 1.39

  1. athe value is the average of five measurements for both the proposed for pure drugs and reported methods
  2. bthe values in parentheses are t- value and F- value. Tabulated values at 95% confidence limit are t = 2.306 and F = 6.338
  3. cSMV was determined by measuring the absorbance directly at λ 335 nm in all methods
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BMC Chemistry

ISSN: 2661-801X

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