BMC Chemistry

Table 5 Application of standard addition technique for determination of SER.DMP and DMP in capsules using the developed chromatographic techniques

From: Chromatographic reversed HPLC and TLC-densitometry methods for simultaneous determination of serdexmethylphenidate and dexmethylphenidate in presence of their degradation products—with computational assessment

Pharmaceutical taken (µg/mL)	HPLC method			TLC densitometric method
	Standard added ^b(μg/mL)	% Recovery of added standard^a		Standard added^b (μg/spot)	% Recovery of added standard^a
	Standard added ^b(μg/mL)	SER.DMP	DMP	Standard added^b (μg/spot)	SER.DMP	DMP
15	10	101.25	99.75	10	100.07	99.95
10	15	99.45	100.69	15	99.95	100.75
5	20	99.52	99.82	20	99.85	99.92
Mean		100.27	100.43		99.95	100.31
% RSD		0.830	0.824		0.963	1.129

^aAverage of three different experiments
^bEach of both drugs

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ISSN: 2661-801X

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