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Table 6 Determination of SER.DMP and DMP in Azstarys® capsules by the proposed methods and the reported method

From: Chromatographic reversed HPLC and TLC-densitometry methods for simultaneous determination of serdexmethylphenidate and dexmethylphenidate in presence of their degradation products—with computational assessment

Parameters

SER.DMP

HPLC method

TLC densitometric method

Reported methoda [5]

Number of measurements

5

5

5

Mean % recovery of SER.DMP

100.43

99.68

99.43

% RSD

0.910

1.085

1.380

Student’s t-testb

1.153 (2.306)

0.457 (2.306)

——

F-valueb

2.260 (6.388)

1.606 (6.388)

——

Parameters

DMP

HPLC method

TLC densitometric method

Reported methoda [5]

Number of measurements

5

5

5

Mean % recovery of DMP

100.43

99.68

99.43

% RSD

0.910

1.085

1.380

Student’s t-testb

1.153 (2.306)

0.457 (2.306)

——

F-valueb

2.260 (6.388)

1.606 (6.388)

——

  1. a Reference method is HPLC using X-terra C18 column using a mixture of trifluoro acetic acid and acetonitrile (70:30 v/v) as mobile phase with a flow rate of 1 mL and UV-detection at 265 nm
  2. b The values in parenthesis are tabulated values of “t” and “F” at (P = 0.05