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Table 2 Response optimization of 23 full factorial design for HPLC–UV separation of PAR and DAN

From: Hydro-organic mobile phase and factorial design application to attain green HPLC method for simultaneous assay of paracetamol and dantrolene sodium in combined capsules

Factor

Goal

Lower

Target

Upper

Weight

Import

Predicted responses

Desirability

tr PAR

Maximize

2.1

2.2

2.2

1

1

2.2

1.000

tf DAN

Minimize

1.1

1.1

1.4

1

1

1.1

1.000

tr DAN

Target

4.0

5.7

7.2

1

1

5.7

1.000

Optimum Conditions: 40% ethanol, 0.2% TEA and pH 4.5

       

Composite Desirability (D) = 1.000