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Table 4 Assay results for the determination of PAR and DAN in pure form by the suggested and official USP methods

From: Hydro-organic mobile phase and factorial design application to attain green HPLC method for simultaneous assay of paracetamol and dantrolene sodium in combined capsules

Compound

Suggested technique

Official USP method [33]

Concentration taken (µg/mL)

Concentration found (µg/mL)

% Found

% Found

PAR

1.0

0.98

98.00

100.57

2.0

1.957

97.85

99.11

5.0

4.911

98.22

100.37

10.0

9.957

99.57

 

20.0

20.066

100.33

 

30.0

29.804

99.35

 

40.0

40.506

101.27

 

60.0

59.823

99.71

 

100.0

100.388

100.39

 

200.0

199.782

99.89

 

Mean

  

99.46

100.02

 ± S.D

  

1.13

0.792

t test

  

0.79 (2.20) *

 

F test

  

2.03 (19.38) *

 

DAN

1.0

0.981

98.10

100.76

2.0

2.016

100.80

98.88

5.0

5.026

100.52

100.45

10.0

9.806

98.06

 

20.0

20.116

100.58

 

30.0

30.322

101.07

 

40.0

39.745

99.36

 

Mean

  

99.78

100.03

 ± S.D

  

1.28

1.01

t test

  

0.29 (2.31) *

 

F test

  

1.62 (19.33) *

 
  1. N.B. Each result is the average of three separate determinations
  2. *The figures between parentheses are the tabulated t and F values at P = 0.05 [32]
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BMC Chemistry

ISSN: 2661-801X

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