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Table 7 Assay results for the determination of PAR and DAN in synthetic mixtures of their pharmaceutical ratio (12:1) by the suggested HPLC technique

From: Hydro-organic mobile phase and factorial design application to attain green HPLC method for simultaneous assay of paracetamol and dantrolene sodium in combined capsules

PAR/DAN ratio

Suggested technique

Official USP method [33]

Concentration taken (µg/mL)

Concentration found (µg/mL)

% Found

% Found

PAR

DAN

PAR

DAN

PAR

DAN

PAR

DAN

12:1

60.0

5.0

61.008

4.999

101.68

99.98

99.68

101.14

 

120.0

10.0

120.084

9.889

100.07

98.89

100.68

100.69

 

180.0

15.0

177.966

15.207

98.87

101.38

99.37

98.58

 

192.0

16.0

193.018

15.920

100.53

99.50

101.05

99.43

Mean

   

100.29

99.94

100.20

99.96

 

 ± S.D

   

1.16

1.06

0.69

0.91

 

t test

   

0.13

0.03

 

(2.45)*

 

F test

   

2.12

1.21

 

(9.28)*

 
  1. N. B. Each result is the average of three separate determinations
  2. *The figures between parentheses are the tabulated t and F values at P = 0.05 [32]
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BMC Chemistry

ISSN: 2661-801X

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