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Table 8 Assay results for the determination of PAR and DAN in their combined capsules by the suggested HPLC technique

From: Hydro-organic mobile phase and factorial design application to attain green HPLC method for simultaneous assay of paracetamol and dantrolene sodium in combined capsules

PAR/DAN ratio

Suggested technique

Official USP method

Concentration taken (µg/mL)

Concentration found (µg/mL)

% Found

% Found

PAR

DAN

PAR

DAN

PAR

DAN

PAR

DAN

Dantrelax compound® 300PAR/25DAN

120

10

117.648

9.865

98.04

98.65

98.04

100.75

150

12.5

152.325

12.606

101.94

100.85

101.94

98.69

200

16.67

199.659

16.489

99.83

99.96

99.83

101.37

Mean

    

99.94

99.82

100.01

100.27

 ± S.D

    

1.95

1.11

0.66

1.15

t test

    

0.06

0.44

(2.78)*

 

F test

    

5.84

1.60

(19.00)*

 
  1. N. B. Each result is the average of three separate determinations
  2. *The figures between parentheses are the tabulated t and F values at P = 0.05 [32]
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BMC Chemistry

ISSN: 2661-801X

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