Table 9 Comparison of greenness report between the suggested and reported HPLC methods adopting NEMI method [16]
Mixture | Method | Mobile phase | Run time (min.) | Flow rate (mL/min.) | Waste (g/run) Run time × flow rate [10] | Greenness profile** |
|---|---|---|---|---|---|---|
Paracetamol and Dantrolene | Reported HPLC method [19] | Methanol: water (55:45, v/v) pH 3 with aqueous formic acid | 12 | 1.0 | 12 |
|
Paracetamol and Dantrolene | Reported HPLC method [20] | Methanol: potassium dihydrogen phosphate (50:50 v/v) pH 3.5 by phosphoric acid | 9 | 1.0 | 9 |
|
Paracetamol and Dantrolene | Proposed HPLC method | Ethanol: water (40:60) pH 4.5 by phosphoric acid | 6 | 0.8 | 4.8 |
|
