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Table 5 IC50 values against FGFR1, VEGFR-2 and RET achieved by the most active candidate 15c

From: Discovery of a new potent oxindole multi-kinase inhibitor among a series of designed 3-alkenyl-oxindoles with ancillary carbonic anhydrase inhibitory activity as antiproliferative agents

Kinase target

IC50 (μM)

FGFR 1

1.287

VEGFR 2(KDR)

0.117

RET

1.185

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BMC Chemistry

ISSN: 2661-801X

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