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Table 7 Docking energy scores (S) in kcal/mol for compound 15c and the co-crystalized ligands in VEGFR-2, FGFR1 and RET active sites

From: Discovery of a new potent oxindole multi-kinase inhibitor among a series of designed 3-alkenyl-oxindoles with ancillary carbonic anhydrase inhibitory activity as antiproliferative agents

Compound

 

(S) in kcal/mol

 

VEGFR-2

FGFR1

RET

15c

 − 12.94

 − 13.06

 − 13.04

Co-crystalized

ligand

 − 15.19

 − 17.00

 − 14.23