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Table 8 Effect of complexes (IC50 = 0.156, 0.125, 0.277 μM, respectively) on the DNA of MCF-7 cells: Comet Damage (%), tail length, DNA in the tail (%), and tail moment

From: Study of novel bidentate heterocyclic amine-based metal complexes and their biological activities: cytotoxicity and antimicrobial activity evaluation

Parameters

Control group mean ± S.E.M.

Treated group mean ± S.E.M.

Complex 1

Complex 2

Complex 3

Value

% D

Value

% D

Value

% D

Comet (damage) (%)

10.5 ± 0.29

10.5 ± 0.35

0%

18 ± 0.17

71.4%

15 ± 0.06

42.8%

 

A

A

 

B

 

C

 

Tail length (μm)

7.8 ± 0.1

7.3 ± 0.02

 − 6.4%

9.33 ± 0.04

27.8%

6.5 ± 0.01

 − 16.6%

 

A

B

 

C

 

D

 

DNA in tail (%)

8.3 ± 0.05

7.6 ± 0.09

 − 8.4%

7.5 ± 0.07

 − 9.6%

7.5 ± 0.03

 − 9.6%

 

A

B

 

B

 

B

 

Tail moment (μm)

0.74 ± 0.01

0.57 ± 0.005

 − 22.9%

0.83 ± 0.02

12.1%

0.56 ± 0.008

 − 24.3%

 

A

B

 

C

 

B

 
  1. Different symbols indicate significant (p < 0.05) different means