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Table 9 Effect of complexes (IC50 = 0.222, 0.126, 0.152 μM, respectively) on the DNA of HeLa cells: Comet Damage (%), tail length, DNA in Tail (%), and tail moment

From: Study of novel bidentate heterocyclic amine-based metal complexes and their biological activities: cytotoxicity and antimicrobial activity evaluation

Parameters

Control group mean ± S.E.M.

Treated group mean ± S.E.M.

Complex 1

Complex 2

Complex 3

Value

% D

Value

% D

Value

% D

Comet (damage) (%)

8.6 ± 0.08

18.8 ± 0.12

118.6%

11.3 ± 0.23

31.4%

12 ± 0.4

39.5%

 

A

B

 

C

 

D

 

Tail length (μm)

5.37 ± 0.02

6.33 ± 0.005

17.9%

7.6 ± 0.17

41.5%

6 ± 0.2

11.7%

 

A

B

 

C

 

B

 

DNA in tail (%)

5.32 ± 0.01

6.99 ± 0.05

31.2%

14.5 ± 0.86

172.5%

9.96 ± 0.09

87.2%

 

A

B

 

C

 

D

 

Tail moment (μm)

0.27 ± 0.006

0.58 ± 0.003

114.8%

1.89 ± 0.04

600%

0.91 ± 0.01

237%

 

A

B

 

C

 

D

 
  1. Different symbols indicate significant (p < 0.05) different means