From: Hybridization of the effective pharmacophores for treatment of epilepsy: design, synthesis, in vivo anticonvulsant activity, and in silico studies of phenoxyphenyl-1,3,4-oxadiazole-thio-N-phenylacetamid hybrids
Compound
Dose (mg/kg)
Time as seconds to stay on rotating bar
8k
2 mg/kg
15.98 ± 2.00*
8L
5 mg/kg
33.47 ± 5.75ns
DMSO
5 ml/kg
34.4 ± 4.48
Diazepam
3.80 ± 0.40***