Table 3 IC50 (μg/ml) of the compounds 3–19
Compound | MCF7 | A549 | HCT116 | PC3 | HePG2 | PACA2 |
|---|---|---|---|---|---|---|
3a | – | – | 44.5 ± 1.3 | – | 19.2 ± 0.6 | – |
3b | – | – | – | – | – | 69.7 ± 1.3 |
4a | 32.4 ± 0.8 | 68.9 ± 0.5 | – | – | – | 24.1 ± 1.0 |
4b | 45.8 ± 1.0 | 17.5 ± 0.4 | 58.4 ± 0.7 | 28.5 ± 0.8 | 84.3 ± 0.7 | – |
5 | – | – | – | – | – | – |
6 | 15.2 ± 0.9 | – | 31.2 ± 0.9 | 31.1 ± 0.9 |  | 40 ± 1.0 |
7 | 16.2 ± 1.6 | – | – | – | – | – |
8 | 48.0 ± 1.5 | – | 68.1 ± 1.0 | – | 17.8 ± 1.3 | 23.5 ± 0.6 |
9a | – | – | – | – | – | – |
9b | – | – | – | – | – | – |
10 | 61.1 ± 1.4 | – | 26.9 ± 0.6 | 11.6 ± 0.8 | – | – |
11a | – | – | – | – | – | 55.4 ± 1.4 |
11b | 48.4 ± 0.8 | – | – | 27.7 ± 0.1 | – | – |
12 | 11.9 ± 0.9 | – | – | – | – | 59.7 ± 0.7 |
13 | – | – | – | – | – | – |
14a | 1.7 ± 0.4 | – | – | – | 37.9 ± 0.9 | – |
14b | 16.8 ± 0.9 | – | – | 18.7 ± 0.2 | 17.5 ± 0.8 | – |
15 | 42.8 ± 0.6 | 54.0 ± 1.7 | – | – | 29.1 ± 0.5 | – |
16a | – | – | – | – | – | – |
16b | 5.7 ± 0.9 | – | – | – | – | – |
17 | – | 34.1 ± 1.5 | 37.8 ± 0.4 | 66.8 ± 2.0 | 8.7 ± 0.8 | 6.4 ± 0.7 |
18a | – | – | – | – | – | – |
18b | 3.4 ± 0.3 | – | – | 19.2 ± 0.9 | 28.1 ± 0.4 | 15 ± 0.9 |
19 | – | – | – | – | 19.4 ± 0.8 | – |
Dox | 26.1 ± 0.1 | 28.3 ± 1.3 | 37.6 ± 0.8 | 23.8 ± 0.2 | 21.6 ± 0.8 | 28.3 ± 0.4 |