Parameters | Unit | Group A | Group B | Group C |
---|---|---|---|---|
AUC(0−t) | µg/L*h | 1081.67 ± 43.81 | 1,267.55 ± 79.35* | 1721.61 ± 219.36** |
AUC(0−∞) | µg/L*h | 1085.49 ± 44.17 | 1272.62 ± 77.99* | 1729.93 ± 218.06** |
MRT(0−t) | h | 2.71 ± 0.10 | 2.76 ± 0.07 | 2.95 ± 0.14* |
MRT(0−∞) | h | 2.76 ± 0.09 | 2.82 ± 0.09 | 3.00 ± 0.14* |
t1/2 | h | 1.34 ± 0.11 | 1.42 ± 0.56 | 1.37 ± 0.16 |
Tmax | h | 1.83 ± 0.41 | 2.00 ± 0.00* | 2.17 ± 0.41* |
CLz/F | L/h/kg | 27.67 ± 1.09 | 23.64 ± 1.35* | 17.59 ± 2.37** |
Vz/F | L/kg | 53.25 ± 3.64 | 48.95 ± 21.13 | 34.80 ± 6.57** |
Cmax | ng/mL | 332.00 ± 52.79 | 396.05 ± 37.19* | 494.51 ± 130.68** |