Sustainable eco-friendly ratio-based spectrophotometric and HPTLC-densitometric methods for simultaneous analysis of co-formulated anti-migraine drugs with overlapped spectra

Table 4 Application of the proposed methods for the analysis of pharmaceutical formulation and results obtained by standard addition technique

^aMean Recovery % ± SD		HPTLC-densitometry		RD		DRZC
^aMean Recovery % ± SD		ASP	MET	ASP	MET	ASP	MET
Migaramx^® oral powder claimed to contain 900 mg ASP and 10 mg MET		99.16 ± 1.27	101.43 ± 1.82	100.74 ± 0.48	100.41 ± 0.88	99.55 ± 1.26	99.81 ± 0.59
Standard addition technique
Pure added (µg/band or µg/mL)		^bMean recovery % ± SD
ASP	MET	^bMean recovery % ± SD
20	5	100.43 ± 1.47	101.76 ± 0.64	99.65 ± 0.64	99.54 ± 0.95	100.41 ± 0.88	99.81 ± 0.59
40	20	99.52 ± 1.23	100.32 ± 1.31	100.83 ± 0.73	100.79 ± 0.53	100.05 ± 1.32	99.53 ± 0.65
60	30	100.82 ± 0.58	100.46 ± 1.25	100.72 ± 1.02	100.32 ± 0.76	100.31 ± 0.85	100.64 ± 0.83

ISSN: 2661-801X