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Table 1 Optimization of DRZ-PM/silica carbon paste selective electrode and obtained the potentiometric response

From: Electrochemically-selective electrode for quantification of dorzolamide in bulk drug substance and dosage form

No

*I.E

Composition (%)

*LOD

mol L−1

*RSD

*R (s)

*C

*P

*S

1

3 (DRZ-PM)

48.5

48.5 (DBP)

47 ± 0.15

1.3

15

2

5 (DRZ-PM)

47.5

47.5 (DBP)

47 ± 0.15

1.4

10

3

10 (DRZ-PM)

45

45 (DBP)

48 ± 0.44

1.7

10

4

15 (DRZ-PM)

42.5

42.5 (DBP)

50 ± 0.12

1.2

9

5

20 (DRZ-PM)

40

40 (DBP)

57 ± 0.1

1 × 10−4

0.8

4

6

20 (DRZ-PM)

40

40 (DOP)

10 ± 0.1

1.2

9

7

20 (DRZ-PM)

40

40 (DBP)

57 ± 0.1

1 × 10−4 mol L−1

0.8

4

8

20 (DRZ-PM)

40

40 (NPOE)

43 ± 0.18

1 × 10−4 mol L−1

1.6

10

9

20 (DRZ-PM)with silica

30

40 (DBP)

59 ± 0.47

1 × 10−4 mol L−1

0.5

10

 

20 (DRZ-PM)with cyclodextrin

30

40 (DBP)

58 ± 0.57

5.96 × 10−5 mol L−1

0.5

10

  1. *I.E: Ion-exchanger, *C: Carbon (pure carbon)%, *P: % of plasticizer, *S: slope (mVdecade−1); *C.R.: concentration range (mol L−1), *LOD: detection limit (mol L−1); *R (s): response time (s); *RSD: relative standard deviation, measurements replicate number = 3.*Selected composition