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Table 2 Electrochemical response of the investigated DRZ-PM/silica selective electrode

From: Electrochemically-selective electrode for quantification of dorzolamide in bulk drug substance and dosage form

Parameter

Value or range

Range

1.38 × 10−4–1 × 10−2 mol L−1

Linearity

 

 Slope (S)

59.00 ± 0.47

 Correlation coefficient (r)

0.993

 Intercept

49.5

 Limit of detection (LOD)*

1 × 10−4 mol L−1

 Working pH range

4.5–8.5

 Response time (Rs)

4 s

 Electrode life time

14 days

 Accuracy** (mean ± SD)

99.46 ± 0.403

Precision (RSD%)

 Repeatability***

1.155

 Intermediate precision****

1.298

  1. *LOD (detection limit) was calculated by interception of the extrapolated lines of nonresponsive and the calibration plots for Nernstian ranges of Fig. 7
  2. **Accuracy: DRZ HCL solution average recovery results (2 × 10−4, 1 × 10−3, 1 × 10−2 mol L−1) analysed in duplicate
  3. ***The intraday (n = 3), RSD% of three concentrations (2 × 10–4, 1 × 10–3&1 × 10-2 mol L−1) was repeated three times within the same day
  4. ****The interday (n = 3), RSD% of three concentrations (2 × 10–4, 1 × 10–3& 1 × 10-2 mol L−1) was repeated three times in three consecutive days
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BMC Chemistry

ISSN: 2661-801X

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