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Table 4 DRZ determination in Xolamol® eye drops using the proposed DRZ-PM/silica electrode

From: Electrochemically-selective electrode for quantification of dorzolamide in bulk drug substance and dosage form

Pharmaceutical formulation

Applied method

Taken conc (mol L−1)

Found conc (mol L−1)

Recovery% ± RSD%

Xolamol eye drop 22.26 mg DRZ HCl/mL

Batch number(VB0113)

Potentiometric titration method

1.00 × 10–2 *

1.00 × 10–2**

1.00 × 10–2

1.0032 × 10–2

100.00 ± 0.20

100.32 ± 0.14

Calibration curve

2.00 × 10–4

1.995 × 10–4

99.75 ± 0.10

1.00 × 10–3

0.999 × 10–3

99.90 ± 0.18

1.00 × 10–2

0.9985 × 10–2

99.85 ± 0.102

  1. *3 mL was taken of 1 × 10−2 mol L−1 DRZ
  2. **9 mL was taken of 1 × 10−2 mol L−1 DRZ
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BMC Chemistry

ISSN: 2661-801X

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