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Table 5 Statistical analysis of the proposed methods to assess dorzolamide HCl in its drug substance using modified DRZ-PM/silica electrode

From: Electrochemically-selective electrode for quantification of dorzolamide in bulk drug substance and dosage form

Parameters

Proposed methods

Reported method (26)

Mean Recovery%

99.46 ± 0.40

99.81 ± 0.20

n

6

7

SD

0.40

0.20

Variance

0.162

0.064

Student t-test

1.84(2.201)

F-Test

2.5 (4.93)

  1. Confidence limit at 95%, SD standard deviation, n number of determinations, values between parenthesises are the critical values of Student t-test and F-value