Facile synthesis and eco-friendly analytical methods for concurrent estimation of selected pharmaceutical drugs in their solutions: application to quality by design, lean six sigma, and stability studies

Table 2 ANOVA data for resolution and retention time responses

Source	Sum of Squares	df	Mean Square	F-value	P-value
Resolution
Model	20.88	9	2.32	19.24	0.0004	Significant
A-Temperature	2.16	1	2.16	17.94	0.0039
B-% ACN	0.4753	1	0.4753	3.94	0.0875
C-pH	10.88	1	10.88	90.25	< 0.0001
AB	1.76	1	1.76	14.56	0.0066
AC	0.7140	1	0.7140	5.92	0.0452
BC	2.02	1	2.02	16.72	0.0046
A²	0.8432	1	0.8432	6.99	0.0332
B²	1.16	1	1.16	9.63	0.0173
C²	0.5764	1	0.5764	4.78	0.0650
Residual	0.8440	7	0.1206
Lack of Fit	0.8440	3	0.2813
Pure Error	0.0000	4	0.0000
Cor Total	21.72	16
Retention time
Model	7.15	9	0.7948	27.30	0.0001	Significant
A-Temperature	0.1688	1	0.1688	5.80	0.0469
B-% ACN	6.12	1	6.12	210.35	< 0.0001
C-pH	0.3301	1	0.3301	11.34	0.0120
AB	0.0103	1	0.0103	0.3539	0.5706
AC	0.0002	1	0.0002	0.0054	0.9436
BC	0.2134	1	0.2134	7.33	0.0303
A²	0.0019	1	0.0019	0.0653	0.8056
B²	0.0022	1	0.0022	0.0765	0.7901
C²	0.2957	1	0.2957	10.16	0.0153
Residual	0.2038	7	0.0291
Lack of Fit	0.2038	3	0.0679
Pure Error	0.0000	4	0.0000
Cor Total	7.36	16

ISSN: 2661-801X