Facile synthesis and eco-friendly analytical methods for concurrent estimation of selected pharmaceutical drugs in their solutions: application to quality by design, lean six sigma, and stability studies

Table 3 Regression and validation items of the suggested UPLC and UV methods for estimation of CFZ and PYD

Parameter	UPLC		RS		MCR
Parameter	CFZ	PYD	CFZ	PYD	CFZ	PYD
Wavelength	254 nm	254 nm	260.3 nm	254.6 nm	220 nm	255.4 nm
Range (µg/mL)	2–100	1–50	3–30	3–30	5–30	5–30
Slope	12,810	2792.5	0.0826	0.0409	31.947	15.295
Intercept	2402.4	394.3	0.0053	0.0005	1.1071	0.643
Correlation coefficient	0.9999	0.9998	0.9998	0.9997	0.9999	0.9999
Repeatability	0.4	0.7	0.2	0.3	0.1	0.2
LOD^a (µg/mL)	0.68	0.29	0.3	0.38	0.2	0.3
LOQ^a (µg/mL)	2.08	0.87	1.15	0.91	0.91	0.6

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