Pharmaceutical formulation | UPLC | UV | Limit % | ||||
---|---|---|---|---|---|---|---|
RS | MCR | ||||||
CFZ | PYD | CFZ | PYD | CFZ | PYD | ||
Kefadim 500 mg IV/IM | 102.19 | 0.19 | 99.86 | 0.26 | 100.26 | 0.22 | 90–110% for CFZ NMT 0.4% for PYD |
102.07 | 0.20 | 102.09 | 0.25 | 100.39 | 0.21 | ||
103.44 | 0.20 | 101.42 | 0.25 | 100.64 | 0.22 | ||
103.44 | 0.19 | 101.61 | 0.24 | 100.51 | 0.22 | ||
100.91 | 0.20 | 103.08 | 0.26 | 100.76 | 0.22 | ||
100.02 | 0.19 | 99.82 | 0.25 | 101.01 | 0.22 | ||
Mean ± RSD | 102.01 ± 1.34 | 0.20 ± 2.80 | 101.31 ± 1.26 | 0.25 ± 2.99 | 100.59 ± 0.27 | 0.22 ± 1.86 | |
Kefadim 1.0Â g IV/IM | 104.85 | 0.18 | 99.28 | 0.27 | 100.14 | 0.18 | |
102.79 | 0.18 | 100.26 | 0.26 | 100.51 | 0.18 | ||
101.67 | 0.17 | 101.58 | 0.27 | 100.76 | 0.18 | ||
101.85 | 0.18 | 103.20 | 0.26 | 100.39 | 0.18 | ||
103.58 | 0.17 | 101.47 | 0.26 | 100.89 | 0.17 | ||
103.26 | 0.18 | 102.15 | 0.27 | 99.38 | 0.18 | ||
Mean ± RSD | 103.00 ± 1.15 | 0.18 ± 2.92 | 101.32 ± 1.37 | 0.27 ± 2.06 | 100.34 ± 0.54 | 0.18 ± 2.29 |