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Table 7 Assay results for the estimation of CFZ and PYD in their pharmaceutical formulation by the suggested methods

From: Facile synthesis and eco-friendly analytical methods for concurrent estimation of selected pharmaceutical drugs in their solutions: application to quality by design, lean six sigma, and stability studies

Pharmaceutical formulation

UPLC

UV

Limit %

RS

MCR

CFZ

PYD

CFZ

PYD

CFZ

PYD

Kefadim 500 mg IV/IM

102.19

0.19

99.86

0.26

100.26

0.22

90–110% for CFZ

NMT 0.4% for PYD

102.07

0.20

102.09

0.25

100.39

0.21

103.44

0.20

101.42

0.25

100.64

0.22

103.44

0.19

101.61

0.24

100.51

0.22

100.91

0.20

103.08

0.26

100.76

0.22

100.02

0.19

99.82

0.25

101.01

0.22

Mean ± RSD

102.01 ± 1.34

0.20 ± 2.80

101.31 ± 1.26

0.25 ± 2.99

100.59 ± 0.27

0.22 ± 1.86

Kefadim 1.0 g IV/IM

104.85

0.18

99.28

0.27

100.14

0.18

102.79

0.18

100.26

0.26

100.51

0.18

101.67

0.17

101.58

0.27

100.76

0.18

101.85

0.18

103.20

0.26

100.39

0.18

103.58

0.17

101.47

0.26

100.89

0.17

103.26

0.18

102.15

0.27

99.38

0.18

Mean ± RSD

103.00 ± 1.15

0.18 ± 2.92

101.32 ± 1.37

0.27 ± 2.06

100.34 ± 0.54

0.18 ± 2.29