Development of a sustainable multianalyte MEKC method for quantitation of the antihyperlipidemic drugs ezetimibe together with three statins. Greenness and whiteness appraisal studies

Table 2 Precision and accuracy for determination of ROS, ATO, EZE and SIM using the proposed MEKC–DAD method

Analyte	Type of analysis	Nominal value (μg/ml)	Found ± SD^a (μg/ml)	RSD (%)^b	E_r (%)^c
ROS	Within-day	20	20.01 ± 0.08	0.40	0.05
		40	40.04 ± 0.19	0.48	0.10
		80	80.14 ± 0.62	0.77	0.18
	Between-days	20	19.86 ± 0.25	1.26	− 0.70
		40	39.82 ± 0.29	0.73	− 0.45
		80	79.94 ± 0.59	0.74	− 0.07
ATO	Within-day	20	20.14 ± 0.19	0.94	0.70
		40	40.13 ± 0.39	0.97	0.33
		80	80.04 ± 0.21	0.26	0.05
	Between-days	20	19.87 ± 0.31	1.56	− 0.65
		40	40.03 ± 0.44	1.10	0.08
		80	79.94 ± 0.35	0.44	− 0.07
EZE	Within-day	20	20.20 ± 0.11	0.55	1.00
		40	40.03 ± 0.11	0.28	0.08
		80	80.19 ± 0.33	0.41	0.24
	Between-days	20	20.13 ± 0.22	1.09	0.65
		40	39.82 ± 0.39	0.98	− 0.45
		80	80.15 ± 0.48	0.60	0.19
SIM	Within-day	20	20.02 ± 0.14	0.70	0.10
		40	40.37 ± 0.09	0.22	0.93
		80	80.02 ± 0.25	0.31	0.03
	Between-days	20	19.92 ± 0.38	1.91	− 0.40
		40	40.18 ± 0.34	0.85	0.45
		80	79.93 ± 0.34	0.43	− 0.09

ISSN: 2661-801X