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Table 4 Application of the proposed MEKC method to the analysis of ROS, ATO, and SIM in their binary dosage forms with EZE

From: Development of a sustainable multianalyte MEKC method for quantitation of the antihyperlipidemic drugs ezetimibe together with three statins. Greenness and whiteness appraisal studies

Cholerose-plus®

External standard

Standard addition

ROS

EZE

ROS

EZE

%Recovery ± SDa

100.48 ± 0.68

99.37 ± 0.30

99.16 ± 0.74

100.18 ± 0.84

RSD%b

0.68

0.30

0.75

0.84

Atoreza®

External standard

Standard addition

ATO

EZE

ATO

EZE

%Recovery ± SDa

99.79 ± 0.78

100.74 ± 0.84

99.17 ± 0.73

99.51 ± 1.16

RSD%b

0.78

0.83

0.74

1.17

Simva-Eze®

External standard

Standard addition

SIM

EZE

SIM

EZE

%Recovery ± SDa

99.75 ± 0.35

99.57 ± 0.11

99.17 ± 0.30

100.14 ± 1.91

RSD%b

0.35

0.11

0.30

1.91

  1. Quantification was carried out at 243 nm for ROS and ATO while at 237 nm for SIM and EZE
  2. aMean ± standard deviation for three determinations
  3. b% Relative standard deviation
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BMC Chemistry

ISSN: 2661-801X

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