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Table 5 Robustness evaluation for the analysis of LIN and CEF mixture using the proposed CZE-DAD method

From: Development, validation and greenness assessment of a new electro-driven separation method for simultaneous analysis of cefixime trihydrate and linezolid in their fixed dose combination

Parameter

LIN*

Peak area ± SD

RSD%

Migration time ± SD

RSD%

Buffer concentration 100 ± 2 m mol

56.70 ± 0.10

0.18

2.53 ± 0.02

0.79

Buffer pH

10.2 ± 0.2 pH unit

57.57 ± 0.15

0.26

2.48 ± 0.03

1.21

Wavelength

 250 ± 2 nm

57.17 ± 0.21

0.37

 

Parameter

CEF*

Peak area ± SD

RSD%

Migration time ± SD

RSD%

Buffer concentration 100 ± 2 m mol

42.91 ± 0.25

0.58

5.50 ± 0.05

0.91

Buffer pH

10.2 ± 0.2 pH unit

43.15 ± 0.17

0.39

5.44 ± 0.03

0.55

Wavelength

285 ± 2 nm

43.45 ± 0.23

0.53

 
  1. * Robustness parameters were determined for a mixture containing 30 µg/mL of each LIN and CEF