Development, validation and greenness assessment of a new electro-driven separation method for simultaneous analysis of cefixime trihydrate and linezolid in their fixed dose combination

Table 6 Application of the proposed CZE-DAD method for analysis of LIN and CEF mixture in pharmaceutical tablets

Laboratory prepared tablets	External Standard		Reference method [39]		Standard Addition
Laboratory prepared tablets	LIN	CEF	LIN	CEF	LIN	CEF
%Recovery ± SD^a	99.84 ± 0.59	99.55 ± 0.94	100.17 ± 0.46	99.59 ± 1.17	100.10 ± 0.54	99.96 ± 0.31
RSD%^b	0.59	0.94	0.46	1.17	0.54	0.31
t	1.00	0.05
F	1.67	1.52

^aMean ± standard deviation for five determinations
^b% Relative standard deviation
Quantification was carried out at the following wavelengths: 250 nm for LIN and 285 nm for CEF
Theoretical values for t and F at P = 0.05 are 2.31 and 6.39, respectively

ISSN: 2661-801X