[1, 8]-Naphthyridine derivatives as dual inhibitor of alkaline phosphatase and carbonic anhydrase

BMC Chemistry

Table 1 In vitro assay results of compound 1a-l against h-CAII, h-CAIX, and h-CAXII. Acetazolamide (AZM) was used as a standard inhibitor

Compounds codes	CAII	CAIX	CAXII
Compounds codes	IC₅₀ (µM) ± SEM^a/% inhibition^b
1a	1.28 ± 0.16	0.86 ± 0.47	0.32 ± 0.07
1b	1.26 ± 0.44	15.1%	1.51 ± 0.72
1c	0.90 ± 0.5	0.70 ± 0.27	0.96 ± 0.28
1d	17.0%	1.36 ± 0.48	2.4 ± 0.98
1e	0.44 ± 0.19	1.61 ± 0.26	0.51 ± 0.41
1f	11.0%	0.99 ± 0.12	4.3 ± 2.2
1 g	0.10 ± 0.04	0.11 ± 0.03	3.05 ± 0.92
1 h	1.46 ± 0.96	0.74 ± 0.51	0.80 ± 0.69
1i	25.0%	0.87 ± 0.51	0.46 ± 0.12
1j	2.14 ± 0.3	1.65 ± 0.98	0.51 ± 0.26
1 k	1.63 ± 0.55	35.1%	1.80 ± 0.42
1 l	1.99 ± 0.71	3.2 ± 1.52	1.50 ± 0.31
Acetazolamide	1.19 ± 0.42	1.08 ± 0.03	1.55 ± 0.37

^an = 3 results were obtained from three individual experiments
^bPercentage of inhibition measured at 100 µM final concentration of selected compounds

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