Table 2 In vitro inhibition assay for compounds 1a-l against b-TNAP and c-IAP. Levamisole and L-phenyl alanine were used as standard

1a

0.38 ± 0.09

0.38 ± 0.15

1b

0.12 ± 0.06

0.90 ± 0.41

1c

1.01 ± 0.31

5.80 ± 1.90

1d

%inh < 30

0.30 ± 0.20

1e

0.32 ± 0.11

0.10 ± 0.02

1f

0.14 ± 0.12

0.97 ± 0.50

1 g

0.63 ± 0.47

0.35 ± 0.21

1 h

33%

37%

1i

%inh < 30

1.03 ± 0.20

1j

%inh < 20

0.46 ± 0.33

1 k

0.36 ± 0.07

0.32 ± 0.11

1 l

0.24 ± 0.06

1.03 ± 0.40

Levamisole

19.21 ± 0.001

–

L-phenyl alanine

–

80.21 ± 0.001