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Table 1 Show the comparison in terms of physical data between the synthesized compounds under grinding and microwave techniques

From: Green synthesis of highly functionalized heterocyclic bearing pyrazole moiety for cancer-targeted chemo/radioisotope therapy

  

2

3

4

5

6

7

8

9

Melting point (oC)

Found

100–102

122–124

172–174

140–142

104–106

222–224

138–140

160–162

Lit*

100–102

120–122

170–172

140–142

106–108

220–222

138–140

160–162

Time “min”

Con

240

240

180

180

180

180

240

420

G

10

12

14

17

16

13

11

14

M.W

2

2.5

2

4

3

2.5

3.5

3

Yield %

Con

80

75

78

76

76

75

81

85

G

89.4

89.1

88.9

87.3

88.7

86.0

89.5

90.8

M.W

96.7

94.5

95.5

94.1

93.3

96.6

95.2

97.4

YE

Con

0.3333

0.3125

0.4333

0.4222

0.4222

0.4167

0.3375

0.2024

G

8.94

7.43

6.35

5.14

5.54

6.62

7.50

6.49

M.W

48.35

37.80

47.75

23.53

31.10

38.64

27.20

32.47

RME

Con

66.19

62.62

58.78

67.66

60.60

58.93

73.16

66.27

G

73.97

74.39

66.99

77.73

70.72

67.57

80.83

76.03

M.W

80.01

78.90

71.96

83.78

74.39

75.90

85.99

81.56

OE

Con

0.6619

0.6262

0.6562

0.7627

0.6400

0.6207

0.7634

0.6884

G

0.7400

0.7439

0.7478

0.8762

0.7469

0.7117

0.8434

0.7898

M.W

0.8001

0.7890

0.8033

0.9444

0.7856

0.7995

0.8972

0.8473

AE

100

100

89.58

88.71

94.69

94.94

95.84

96.26

  1. *Lit. literature value, YE yield economy, RME reaction mass efficiency, OE optimum efficiency, AE atom economy, Con. conventional, G. grinding, M.W. microwave