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Table 2 Anticancer activity of the synthesized pyrazole derivatives against HepG2 and HCT-116 cell lines

From: Green synthesis of highly functionalized heterocyclic bearing pyrazole moiety for cancer-targeted chemo/radioisotope therapy

Comp

In-vitro Cytotoxicity IC50 (µM)a

HepG2

HCT-116

5-Fub

7.86 ± 0.5

5.35 ± 0.3

2

9.2 ± 2.8

7.7 ± 1.8

3

22.8 ± 2.1

29.4 ± 2.3

4

14.5 ± 2.8

15.2 ± 2.4

5

8.8 ± 5.1

13.8 ± 3.9

6

91.4 ± 4.2

51.0 ± 2.7

7

10.2 ± 2.1

13.1 ± 2.3

8

12.1 ± 5.1

17.4 ± 3.9

9

55.7 ± 2.7

33.6 ± 2.1

  1. aIC50 (µM): 1–10 (very strong). 11–20 (strong). 21–50 (moderate). 51–100 (weak) and above 100 (non-cytotoxic)
  2. b5-Fu: 5-Fluorouracil
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BMC Chemistry

ISSN: 2661-801X

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