Development of an eco-friendly HPLC method for the stability indicating assay of binary mixture of ibuprofen and phenylephrine

Table 1 System suitability parameters of the proposed HPLC method

Parameter	IBU	PHE	Reference values [47]
Retention time (t_R) [min]	3.2	7.0	NA
Resolution (R_s)^a	7.86		R_s > 1.5
Selectivity factor (α)^a	1.71		α > 1
Tailing factor (T)	0.97	1.71	T < 2
Capacity factor (K’)	2.73	5.30	1 < K’ < 10
Column efficiency (N)	2196.32	2080.36	N > 2000
Height equivalent to theoretical Plate (HETP) [mm]	0.0198	0.0455	NA

^aResolution and selectivity factors are determined between the peaks of IBU and PHE

ISSN: 2661-801X